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The CMT-Association CMT-Level-II exam, also known as the Chartered Market Technician Level II exam, is a comprehensive assessment of an individual's knowledge and skills in technical analysis and market forecasting. This certification is designed for professionals working in the field of financial markets and investment analysis.
The CMT-Level-II course provides participants with a deep understanding of advanced technical analysis concepts and their application in financial markets. The following is a general outline of the key areas covered in the certification program:
1. Market Analysis and Theory:
- Understanding market structure and the role of supply and demand.
- Exploring different market trends and phases.
- Applying Dow Theory and other market theories.
2. Elliott Wave Theory:
- Understanding the principles of Elliott Wave Theory.
- Identifying wave patterns and their significance.
- Analyzing market cycles and corrective patterns.
3. Fibonacci Analysis:
- Exploring Fibonacci ratios and their application in technical analysis.
- Using Fibonacci retracements and extensions to identify support and resistance levels.
- Applying Fibonacci time zones in market forecasting.
4. Advanced Chart Patterns:
- Recognizing and interpreting advanced chart patterns, such as double tops/bottoms, head and shoulders, triangles, and wedges.
- Understanding the significance of these patterns in trend reversal and continuation.
5. Oscillators and Indicators:
- Using momentum oscillators, such as RSI (Relative Strength Index) and Stochastic Oscillator, to identify overbought and oversold conditions.
- Analyzing volume indicators and their role in confirming price movements.
- Applying moving averages and other trend-following indicators.
6. Market Breadth Analysis:
- Understanding market breadth indicators, such as advance-decline lines and McClellan Oscillator.
- Interpreting market breadth data to gauge market strength or weakness.
- Using breadth analysis to confirm or diverge from price trends.
The CMT-Level-II exam assesses candidates' understanding and application of advanced technical analysis techniques in financial markets. The exam objectives include, but are not limited to:
1. Demonstrating a comprehensive understanding of market analysis and theory.
2. Applying Elliott Wave Theory to identify market cycles and patterns.
3. Utilizing Fibonacci analysis to identify support and resistance levels.
4. Recognizing and interpreting advanced chart patterns.
5. Using oscillators and indicators to assess market momentum and trend strength.
6. Analyzing market breadth indicators to gauge overall market health.
The CMT-Level-II certification program typically includes comprehensive training provided by the CMT-Association or authorized training partners. The syllabus provides a breakdown of the courses covered throughout the course, including specific learning objectives and milestones. The syllabus may include the following components:
- Introduction to the CMT-Level-II exam overview and certification process
- Market Analysis and Theory
- Elliott Wave Theory
- Fibonacci Analysis
- Advanced Chart Patterns
- Oscillators and Indicators
- Market Breadth Analysis
- exam Preparation and Practice Tests
- Final CMT-Level-II Certification Exam
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CMT Level II
http://killexams.com/pass4sure/exam-detail/CMT-Level-II Question: 71
Which of the following factors would NOT increase the predictive power of a dark cloud cover pattern?
A . The dark cloud cover occurs in the middle of a trading range
B . During a downtrend, a white real body with shaven head and bottom followed by a black body also with a shaven
head and bottom
C . If the second day of trading opens above a resistance level and then fails
D . Heavy volume on the second day indicates a buying blow o Answer: A Question: 72
Which would be the MOST useful aspect of a cycle in studying the relationship between cycles of different lengths?
A . Phase
B . Period
C . Amplitude
D . None of the above Answer: A Question: 73
Using the Point-and-Figure method what is the standard method used to portray the volume on the chart?
A . This is to multiply the volume occurring when each box was in operation
B . This is to sum up the volume occurring when each box was in operation
C . This is to divide up the volume occurring by each box was in operation
D . It is, to sum up, the volume that occurs when every box is not in use Answer: B Question: 74
What is the measuring objective for a symmetrical triangle formation?
A. A trendline from the top of the pattern parallel to the lower trendline
B. The height of the base of the triangle
C. Both A. and B. are valid techniques
D. Neither A. nor B. is a valid technique Answer: C Question: 75
Which of the following asset classes as a leading indicator for the stock market?
A . Bonds
B . Bullion
C . Precious metal
D . Energy Answer: A Question: 76
Which of the following would NOT be true in designing a trading system utilizing bands?
A . Buy when prices penetrate the upper band
B . Close out longs when prices reverse and go below the center of the band
C . Close out shorts when prices reverse and go below the center of the band
D . Sell when price breaks below the lower band Answer: C Question: 77
Which of the following BEST describes the rule of alternation?
A . Downtrends follow uptrends
B . Complex patterns follow simple patterns
C . Price follows volume
D . Prices alternate in Fibonacci sequences Answer: B Question: 78
Which of the following BEST describes equity market performance during the presidential election cycle:
A . Market has its strongest year during first year of presidents term, posts its worst returns during the pre-election
year and slightly negative returns in election years
B . Market has an above average year during first year of presidents term, posts negative returns during the pre-
election year and its strongest returns in election years
C . Market has a below average year during first year of presidents term, posts its strongest returns during the pre-
election year or in the election year
D . Market has a below average year during first year of presidents term, posts its strongest returns in the second year
and reasonably strong returns during the pre-election and election years Answer: C Question: 79
Can stock prices be normally distributed and are stock returns normally distributed?
A . No, you can not have negative prices and every number is possible with any normal distribution. Yes, stock returns
are normally distributed
B . Yes, you can not afford negative prices and with any usual distribution, any number is possible. No, stock returns
are normally distributed
C . Yes, you can not afford negative prices and with any usual distribution, any number is possible. Yes, stock returns
are normally distributed
D . No, you can not have negative prices and every number is possible with any normal distribution. No, stock returns
are normally distributed Answer: A Question: 80
Allen Johnson, CMT, is working in the Singapore office of German Investment Corporation. From an informal
conversation, Allen learns that the companys most exact annual report contains misappropriated information. No one
at the Singapore office expresses concern, however, because there has been no breach of Singapores law.
A . do nothing because the branch is outside of German jurisdiction.
B . seek advice from the company counsel to determine appropriate action.
C . do nothing because the branch is outside of Singapores jurisdiction.
D . disassociate himself from the case with a written report to his supervisor. Answer: B
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Most national and international standards regarding bioburden, sterilization, or environmental testing recommend establishing alert and action levels to demonstrate continued control over a process or product.
ISO 11737-1:2006 provides guidance on establishing bioburden alert and action levels.1 Clauses A.8.5â8.7 supply general guidelines for setting environmental or bioburden levels. This guideline does not dictate how to use the data to establish action and alert levels, nor does it provide guidance on how to interpret the data depending on the sterilization modality in use.
The standard for radiation sterilization, ISO 11137-2:2006, assumes that dose audits are being performed quarterly. Clause 10.1 states
A review of environmental and manufacturing controls, together with determinations of bioburden should be conducted in conjunction with sterilization dose audits. If the review indicates lack of control, appropriate action should be taken.
No definition is provided for the phrase âindicates lack of control.â It is clear that some criteria should be established. Most companies comply with this requirement by establishing alert and action levels for bioburden and environmental counts.
There are many factors involved in establishing bioburden alert and action levels in a variety of situations.
The 11737-1 document discusses the fact that bioburden data seldom fit into a normal distribution (i.e., a bell-shaped curve). In evaluating bioburden data consider whether it is important that the data fit a standard statistical model (e.g., normal distribution). That the data fit a standard statistical model is less critical than whether the established levels are based on empirical data and whether they provide safety from a sterilization perspective.
One primary reason that bioburden data do not fit a normal distribution is due to bioburden spikes. It is common to obtain most bioburden values near the mean but also to occasionally have a value that is well above the mean (i.e., a bioburden spike). Bioburden spikes are common in the medical device industry, especially with manual assembly.
The other main reason for bioburden data not fitting a normal distribution is because of the frequent occurrence of zero colony forming units (CFUs) results (e.g., <1 CFU per sample). Standard distribution in this case may be zero; thus, use of standard distributions is impossible, and a different approach is required.
Alert and Action Levels
For alerts and actions, some use the term limits rather than levels. The term limit implies that a product has been effected by an excursion above that value. Use of levels does not imply that the product has automatically been impacted and is generally preferred. A search into established documents and standards provides definitions regarding alert and action levels (or limits). 2â5
Alert Level. Indicates when a process might have drifted from normal operating conditions. An investigation may be performed and corrective action may be implemented, but no action is required. It can be assumed that repetitive excursions above the alert level may be addressed as if it were an action level.
Action Level. Indicates that a process has drifted from normal operating conditions. An investigation must be performed and corrective action must be implemented.
Manufacturers are responsible for setting their own internal specifications for bioburden and environmental alert and action levels. Alert and action levels should be used as a means to monitor manufacturing processes and not as stand-alone product acceptance criteria.
Neither alert nor action levels should be based solely on environmental or bioburden counts without considering the method of sterilization and the amount of overkill in the cycle. In setting the levels there should be a balance between demonstrating adequate control over bioburden without frequently triggering the alert and action levels. Setting levels is not purely a mathematical exercise. It also involves looking at the proposed levels with common sense.
TNTCs, Spreaders, and Spikes
A bioburden or environmental agar plate may have growth covering the entire surface where distinct colonies cannot be enumerated. These are usually called too numerous to count (TNTC) or spreaders. TNTC describes individual colonies that are indistinguishable because of high numbers of colonies on the filter or plate. Spreaders describe one or more colonies that have covered a portion of or the entire filter or plate. Spreading can be caused by particulates, the nature of the microorganisms, or by fluid on the filter or plate.
TNTC results should not be assigned a CFU value. Using an assigned value beyond the countable range, such as 300, would likely result in an underestimation of the bioburden. In review of any bioburden data, a TNTC result likely indicates a bioburden problem and signals an investigation. The investigation may call for additional testing.
Spreaders do not allow for an accurate count. The count should be discarded when gathering historical data to establish bioburden levels. Spreaders generally indicate a problem with the test method.
Occasionally, spikes are observed in bioburden testing. Currently there is no harmonized definition for a bioburden spike. One common definition is an individual value that is greater than or equal to twice the mean.
Spikes or outliers should be investigated. If they are not true values, then either that value or the entire data set should be discarded. If the investigation determines that they are true values, there may be a bioburden problem in the manufacturing or testing process. It is unwise to set alert and action levels while such a problem is present. If possible, the cause of the spike should be identified and corrected. If this is not done, infrequent spikes could eventually become more frequent.
As part of the investigation, determine whether the spike value raises a potential concern regarding the ability of the current sterilization cycle to provide product that is sterile to the desired sterility assurance level (SAL). This evaluation varies depending on the sterilization mode used and on the bioburden counts at the time of the validation (see Table I).
Each product or product family should be evaluated and established independently, based on historical trends.
When establishing levels for a new product, use initial or temporary levels until enough data are gathered to establish long-term levels.
Initially test the samples more frequently (e.g., weekly or monthly) to establish a baseline. With these baseline data, temporary alert and action levels can be established. Testing on a typical basis (e.g., quarterly) for the remainder of the year will result in sufficient data for determining long-term alert and action levels.
Three initial sets of data representing three batches can provide a good statistical basis for temporary levels. Use of the same mathematical approaches for establishing temporary versus long-term levels is appropriate with the understanding that the temporary levels may be triggered more frequently.
Create a plan for setting long-term alert and action levels. It should cover the transition of temporary to long-term levels and the frequency of reevaluation.
Once sufficient bioburden data have been gathered, long-term alert and action levels should be established. When gathering data, consider the following to ensure that sufficient data representative of the product have been gathered:
Samples should represent the entire lot. If a manufacturing batch is made specific for testing, extra care must be taken to ensure that the testing batch is representative of routine manufacturing. 2
Bioburden data should be gathered over an extended period of time. It is typical to gather data over one year. 2
At least four sets of data should be used. As more data are gathered, the margin of error decreases. For example, one set of 10 samples per quarter of the year (40 data points) generally provides sufficient trending to establish levels.
Employ a validated recovery efficiency for product bioburden levels. A recovery efficiency validation should be performed for each sample product type (e.g., minimum of three samples) and applied to all data points before data evaluation begins. If multiple recovery efficiencies are determined over time, take the mean of all recovery efficiencies and add them to each set of data. Applying the same recovery efficiency to all data provides for less variation when comparing bioburden estimates and is applicable as long as the same extraction method is used for each set of data. In the bioburden standard, derive the correction factor from the recovery efficiency.
Using standard deviations to set levels is a simple and easy approach. A misleading argument against using standard deviations is that microbiological data may not fit a normal distribution. However, the standard deviation is a useful measure of the dispersion of the data, even if data are not normally distributed.
As a larger sample size of bioburden data becomes available, a move toward a normal distribution may not always be seen. Although a larger sample size could result in a normal distribution of microbiological data, the presence of even a single very high value could result in the data not being normally distributed.
Additionally, a larger sample size of bioburden may not necessarily move toward a normal distribution if there is no growth (e.g., 0 CFU observed). In this situation, the sterilization method may be used to establish the alert and action levels. Another option is to use other distributions and their corresponding statistics to establish levels. Although low bioburden data are said to follow a Poisson distribution, in our evaluation of 47 data sets of product with high bioburden, the Poisson distribution was generally not found.
It is not desirable that the alert level be triggered often, as that would be an indication that there is either too much variability in the bioburden results or that the alert level is too low.
It is best to use the bioburden estimate to establish values rather than bioburden averages or maximum values. This would require that a recovery efficiency be validated for each product type to calculate the bioburden estimate. For environmental monitoring, the bioburden average would be used because a recovery efficiency is generally not performed.
Table IIa: This table shows bioburden data-monthly monitoring. Three initial sets of data representing three batches can provide a good statistical basis for temporary levels.
Table IIb. From a bioburden perspective, a comparison of the first three months (See table IIa) versus the entire year shows the bioburden estimate and bioburden estimate plus standard deviations are similar. This demonstrates that, as the manufacturing process was refined over time, there was not a significant change and the bioburden is similar. Â
Initial Evaluation of the Data
Tests are usually performed monthly for the first quarter, then quarterly for the rest of the year. Using bioburden data from the product in question, the mean, standard deviation, and bioburden estimate for each set can be calculated as well as the overall mean, average standard deviation, and average bioburden estimate. The sum of aerobic bacterial and fungal data for each sample could be used in all calculations.
Additional calculations were performed to determine the bioburden estimate plus two and three standard deviations as well as the bioburden estimate times 10 (see Table II, parts a,b, and c).
From a bioburden perspective, a comparison of the first three months versus the entire year might show that the bioburden estimate and bioburden estimate plus standard deviations are similar. This would demonstrate that, as the manufacturing process was refined over time, there was not a significant change and the bioburden is similar.
Using standard deviations to establish the bioburden levels is similar to the ânormal distribution approachâ in PDA TR13.2 The alert level can be set at two standard deviations above the historical bioburden estimate, and the action level can be set at three standard deviations above the historical bioburden estimate. This approach results in tight alert and action levels, which would be appropriate for bioburden-based methods such as radiation.
For radiation sterilization using VDmax, there is an established bioburden count that should not be exceeded, which is the maximum bioburden count permitted in the sterilization table being used in ISO 11137-2 and ISO 13004.1.1,6 For example, for 25 kGy, the maximum allowable bioburden count is 1000 CFUs. This would be an example of when the term limit might be appropriate.
When establishing levels for overkill-based methods (e.g., EtO), alert and action levels could be based using the bioburden estimate + 3 Ă standard deviations and bioburden estimate Ă 10, respectively. A good limit for such products using overkill methods could be when the bioburden approaches or exceeds the titer of the biological indicator. The amount of safety provided in overkill cycles should allow for greater flexibility in the alert and action levels.
Evaluation of Data Normality
The statistical analysis system (SAS) PROC UNIVARIATE was used to evaluate the normality of 47 different data sets (10 samples per data set). The following four different statistical tests were used in these evaluations: Shapiro-Wilk, Kolmogorov-Smirnov, Cramer-von Mises, and Anderson-Darling. Each of these tests did agree reasonably well on the determination of the normality of each of these data sets. Many data sets were found to be abnormal due to a single outlier, which was more than twice the standard deviation beyond the mean (33 out of 47, or 70%).
In the evaluation of these data sets, it was determined whether each data set had a single outlier, which was defined as a single data point more than twice the standard deviation beyond the mean (i.e., mean + 2 standard deviations). Most data sets were either abnormal due to an outlier or normal due to no outlier (39 out of 47 or 83% were deemed abnormal). This result demonstrates that using the SAS program may be a simple and reasonably accurate way to determine whether a given data set has an influential outlier.
When the initial sets of 10 were grouped into sample sizes of 20 or 30 data points (based on product type) and evaluated as described earlier, the data did not become normal solely based on a larger sample size. In fact, the rule of thumb described worked with each of the data sets in determining normality (100%).
There are many factors involved in establishing alert and action levels for product and environmental bioburden. A thorough review of bioburden data can assist in selecting the best approach for the situation. The approaches discussed here have functioned well for a variety of product and sterilization types.
There is often discussion in the industry regarding the appropriateness of standard distributions for evaluating bioburden data. Fitting the bioburden data into a specific statistical distribution is less critical than understanding the ranges of bioburden over time.
An important part of this process is having a good definition for alert and action levels and understanding what should occur when each is triggered. Different sterilization types should require different numerical levels as well as specified follow-up actions.
SO 11737-1:2006, âSterilization of Medical DevicesâMicrobiological MethodsâPart 1: Determination of a Population of Microorganisms on Productsâ (Geneva: International Organization for Standardization, 2006).
PDA Technical Report 13, âFundamentals of an Environmental Monitoring Programâ (Bethesda, MD: Parenteral Drug Association, 2001).
USP <1116>, âMicrobiological Control and Monitoring of Aseptic Processing Environmentsâ (Rockville, MD: United States Pharmacopoeial Convention, 2012)
USP <1231>, âWater for Pharmaceutical Purposesâ (Rockville, MD: United States Pharmacopoeial Convention, 2012)
Code of Federal Regulations 21 CFR 211.
ISO 13004, âSterilization of Healthcare Productsâ RadiationâSubstantiation of Selected Sterilization Dose: Method VDmaxSDâ (Geneva: International Organization for Standardization, July 2013 [not yet published]).
Martell Wintersis a senior scientist at Nelson Laboratories, where he has worked for 18 years. He has been involved in writing AAMI/ISO and AATB documents for 15 years. Winters is a registered microbiologist and the specialist microbiologist.Â Esther Patchis study director II for Nelson Laboratories. She graduated with a degree in chemistry with an emphasis in biochemistry and a minor in biology from Erskine College and Seminary (Due West, SC). She is a national registered biologist.Â Wendy WangsgardisÂ bioburden department scientistÂ and has been with Nelson Laboratories for eight years. She is involved with the radiation sterilization, microbiological methods, sterility assurance level, and other working groups of AAMI.Â Harry Busharis an independent statistician currently employed part-time by FDA. He has served as a member of the AAMI Radiation Sterilization Subcommittee and the Gamma Radiation Sterilization Working Group.Â Ashley Ferryis a quality assurance investigator at Nelson Laboratories. Ferry also audits testing to ensure compliance with cGMPs, ISO/AAMI, USP, and internal SOPs and STPs. She is a registered microbiologist.Â
Thu, 30 May 2013 12:00:00 -0500entext/htmlhttps://www.mddionline.com/sterilization/establishing-bioburden-alert-and-action-levelsGordon Scott
Gordon Scott has been an active investor and has provided education to individual traders and investors for over 20 years. He is a licensed broker, an active trader, and proprietary day trader.
Gordon teaches the Investopedia Academy's Penny Stock Trading course, but his background in instruction is broad and deep. From 2013 to 2018 he was the Managing Director of the Chartered Market Technician (CMT) designation's examination program for the CMT Association (cmtassociation.org). The CMT is a globally-accepted technical analysis credential in the financial industry.
Gordon has over 15 years experience as a trading coach. For four years, he was the content manager at Investools, which publishes research and commentary on trading strategies. Gordon developed an online curriculum and oversaw its growth during the Thinkorswim and TD Ameritrade mergers.
Gordon's career also includes 10-years with International Business Machines Corporation (IBM), where he developed instructional materials and business process refinement. He also was an Adjunct Instructor at Brigham Young UniversityâOrganizational Strategy and Leadership department.
Gordon is co-author of the book,Â Invest to Win (McGraw-Hill 2013),Â with Toni Turner. The book provides insight on investing approaches and in managing a bullish portfolio known as theÂ GainsMaster InvestingÂ method.
Tue, 07 Nov 2023 01:58:00 -0600entext/htmlhttps://www.investopedia.com/contributors/82594/Stella Osoba
Stella Osoba enjoys a distinguished career as a financial, legal, and business writer, a technical analyst, and an independent trader. She produces a wide range of content for print, digital, blog, multimedia, and animation projects. Stellaâs work includes articles on behavioral finance, trading, and technical analysis. An attorney, Stella left a career in law to pursue freelance writing, teaching, and lecturing. Her deep experience and knowledge base include the disciplines of transactional analysis, financial report analysis, and business litigation; statistical and technical analysis of price patterns, volume history, and measures of trend, momentum, and volatility; trading, risk management, inter-market analysis, behavioral finance, market history, and ethics.
Stella is active in the CMT Associationâa global credentialing body with nearly 15 years of service to the financial industry. She was a co-founder and chair of Women in Technical Analysis, a chapter of the CMT Association, which is designed to increase opportunities for women to network and form meaningful contacts in the finance industry. Stella has worked for Wiley Publishing Company to develop material for their online CMT Test Bank and was a grader for the CMT Level 111 exam. Stella is frequently chosen to lead initiatives that require skill in assessing technical data, and serves as a mentor and teacher to traders and other professionals in financial services.
Stella was admitted as a Barrister-at-Law in England and Wales and is a member of Middle-Temple Inn of Court. She studied law at Warwick University School of Law (London), She is also admitted to the Bars of New York and California. She is aÂ Chartered Market Technician (CMT).
Mon, 16 Nov 2015 05:34:00 -0600entext/htmlhttps://www.investopedia.com/contributors/53997/'Son of a Sinner' Jelly Roll reigns at CMT Music Awards show
NASHVILLE, Tenn. â âSon of a Sinnerâ singer Jelly Roll was the big winner at the CMT Music Awards, as the rapper-turned-country singer took home three awards on Sunday as an outsider who won over fans with his confessional songs.
The tattooed singer got emotional during the show in Austin, Texas, which aired on CBS, as he thanked the country radio industry for its acceptance and shouted out to those who felt like him.
âYou can be whatever you want to be. I promise you that. I told them that I wanted to be a country singer and I am standing here at the CMT Awards with the male video of the year, baby,â he shouted.
Earlier in the night, he brought a choir out for his prayer-themed song âNeed a Favorâ and got the crowd to raise their hands to the roof.
The show started off with a somber tone as country singer and co-host Kelsea Ballerini read off the names of six victims of a school shooting killed Monday in Nashville, Tennessee. She noted how she shared their pain, explaining that in 2008 she witnessed a school shooting in her hometown high school cafeteria in Knoxville and prayed for âreal actionâ that would protect children and families. Earlier in the evening, country artists wore black ribbons on the red carpet to honor victims of the shooting.
But the show prioritized nostalgia overall as performances merged rock, blues and country straight from the heart of Texas, mixing in tributes and covers alongside newer artists and fan-favorite hit songs.
Country superstar and five-time Grammy winner Shania Twain was given the Equal Play Award, recognizing her for being a âvisible and vocal advocateâ for diverse voices in country music. Texas native and Grammy-winning rapper Megan Thee Stallion introduced Twain and the pair danced and hugged to Twainâs hit, âMan, I Feel Like a Woman.â
The lyrics to the song became an undercurrent to a decades-long career of advocacy, Twain said.
âI promise I will continue to champion the many outstanding country artists that are not currently played, they are not currently streamed, toured, signed or awarded at the level they deserve,â Twain said. âI believe in an all-inclusive country music.â
Lainey Wilson won twice with female video of the year for âHeart Like a Truckâ and collaborative video of the year for âWait in the Truckâ with HARDY.
âMy heart is âbout to beat right out my chest, Iâll be honest with yâall,â Wilson said after winning female video of the year, calling the hit song an anthem for surviving the âscratches, the dents and the bumps along the way.â
Co-host Kane Brown took home the last award of the night with his wife, Katelyn, winning video of the year for their duet, âThank God.â
âThis is all so new to me. And when we recorded this song a year ago, I never in my life would ever think this was ever going to happen,â Katelyn Brown said.
Later in the show Ballerini took to the stage flanked by drag artists, as states across the country consider legally limiting drag show performances. The Tennessee native sang âIf You Go Down (Iâm Going Down Too)â and danced with Kennedy Davenport, Jan Sport, Manila Luzon and Olivia Lux, all stars of the show âRuPaulâs Drag Race.â
Tennessee was the first state to place strict limits on drag show performances, which were set to take effect this month. The law has been temporarily blocked after a lawsuit was filed earlier this week.
Collaborations took center stage for most of the three-hour show. Country Music Hall of Famer Wynonna Judd and Ashley McBryde performed a cover of Foreignerâs âI Want to Know What Love isâ while heavy fog rolled over the stage and into the crowd.
Pop singer Stefani performed her No Doubt mid-1990s pop-punk hit âJust a Girlâ alongside country singer Carly Pearce. Rocker Alanis Morissette brought more of the â90s rock to the stage with a group performance of âYou Oughta Knowâ featuring Wilson, Ingrid Andress, Madeline Edwards and Morgan Wade.
Carrie Underwood, the most-awarded artist in CMT history with 25 awards, performed âHate My Heartâ as fireworks lit up the Austin night. Four-time Grammy winner Clark Jr. performed a tribute to the late Texas guitarist Stevie Ray Vaughn at the top of the show.
Southern rockers Lynyrd Skynyrd were honored with a tribute performance following the death in March of the last original member, Gary Rossington. ZZ Topâs Billy Gibbons, Slash of Guns Nâ Roses and the Allman Brothersâ Warren Haynes and Chuck Leavell wrapped the show with singers Paul Rodgers and Cody Johnson and backup vocals from LeAnn Rimes and Judd.
Sun, 02 Apr 2023 21:33:00 -0500en-UStext/htmlhttps://triblive.com/aande/music/son-of-a-sinner-jelly-roll-reigns-at-cmt-music-awards-show/September home sales drop to the lowest level since the foreclosure crisis
Sales of previously owned homes dropped 2% in September from August to a seasonally adjusted, annualized rate of 3.96 million units, according to the National Association of Realtors. Sales were 15.4% lower compared with September 2023.
This is the slowest sales pace since October 2010, during the Great Recession, when the market was in the midst of a foreclosure crisis. As a comparison, just two years ago, when mortgage rates hovered around 3%, home sales were running at a 6.6 million pace. The average rate on the 30-year fixed today is right around 8%, according to Mortgage News Daily.
"As has been the case throughout this year, limited inventory and low housing affordability continue to hamper home sales," said Lawrence Yun, NAR's chief economist. "The Federal Reserve simply cannot keep raising interest rates in light of softening inflation and weakening job gains."
There were 1.13 million homes for sale at the end of September, down more than 8% from a year ago. Inventory is now at a 3.4-month supply, which is slightly better than last year, but only because sales have dropped so much. Supply is based on the current sales pace.
Adding to higher mortgage rates, the median price of a home sold in September was $394,300, up 2.8% year over year. Roughly 26% of home sold above list price, due to the lack of supply which is resulting in bidding wars.
First-time buyers made up just 27% of sales. Historically, they make up about 40%.
While sales were lower across all price points, they fell the least on the higher end. That's because there is more supply at the higher price points and because higher-end buyers can often use cash. Mortgage demand is now at the lowest level since 1995, according to the Mortgage Bankers Association.
All-cash sales made up 29% of all September transactions, up from 27% in August and up from 22% in September of last year.
"Although affordability is a headwind, the renewed upward energy that followed the Fed's September projections might have prompted some shoppers to rush to the closing table, lest they face higher mortgage rates and even worse affordability in the months ahead. If so, this could mean a bigger lull in sales activity in the coming months," said Danielle Hale, chief economist for Realtor.com, in a release.
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Clarification: This story has been updated to clarify that sales were 15.4% lower compared with September 2023.
Thu, 19 Oct 2023 02:00:00 -0500entext/htmlhttps://www.cnbc.com/2023/10/19/september-home-sales-drop-to-lowest-level-since-the-foreclosure-crisis.htmlThe best action movies on Netflix right now
The best action movies onÂ Netflix right now include some all-time classics, at least one major 2023 summer blockbuster, and a whole lot more. But, like with any collection on Netflix, the library is always changing. There are a few quality additions for November, and weâre keeping tabs on them for you to curate this list to help you keep up the action on your next movie night.
Save on everything from laptops and tablets, to coffee makers and air purifiers, and a whole host of Apple tech like iPad, Apple Watch and even the latest M3 MacBooks, as well as smart home essentials like the Amazon Echo and smart bulbs.
Digital Trends streaming roundup
Mon, 06 Nov 2023 10:01:00 -0600entext/htmlhttps://www.digitaltrends.com/movies/best-action-movies-on-netflix/Out of All the Action Comedy Hunks, John Cena Gets the Assignment MostNo result found, try new keyword!Back in 2006, when John Cena was just known as a WWE wrestler who was headlining scrappy B-level action movies like The Marine, the idea of him being a poster child for modern action comedy hunks ...Thu, 02 Nov 2023 13:13:00 -0500en-ustext/htmlhttps://www.msn.com/Innovation in action
The University of Delawareâs STAR Campus is an example of innovation-based economic development, where public-private partnership in university-anchored ecosystems can help power the stateâs economy, bolster business creation and innovation, and foster workforce-development and student success.
Article by Karen B. RobertsPhotos by Kathy F. Atkinson and Dave LevandoskiOctober 26, 2023
Norbert MĂłrucz traveled more than 4,400 miles to attend the 2023 international conference of the Association of University Research Parks in Delaware, Oct. 16-19. MĂłrucz is president of the Association of Science and Technology Parks in Budapest, Hungary, an association of 20 technology parks and 14 science parks.Â
A new AURP member and first-time conference attendee, MĂłrucz was eager to learn about U.S. models for technology and innovation park development, to network and to make connections with potential American partners.Â
âUniversities today are not just for education and research, but also for technology development and innovation, and business,â MĂłrucz said. âWe want to set up joint ventures, collaborate and provide a pipeline and soft landing for Europeans to come here, but need advice on how to go about this.â
UD President Dennis Assanis welcomed the attendees to Delaware, noting the alignment between the conference theme of innovation powered by people, places and purpose and the culture developing across the STAR Campus.
He pointed out that UDâs STAR Campus is an example of innovation-based economic development, where public-private partnership in university-anchored ecosystems can help power the stateâs economy, bolster business creation and innovation, and foster workforce-development and student success. With more than 30 companies on STAR and more than 1 million square feet of modern labs, classrooms, clinical spaces and offices, connected by greenspace, there is a neighborhood feel that encourages creativity, collaborations and community building.
âThese kinds of technology and innovation hubs are at the heart of what I think is our modern-day land-grant mission. The ecosystem that grows up around a particular industry â for example, biopharmaceuticals here at STAR Campus â becomes self-perpetuating,â said Assanis, who was appointed by President Biden to the President's Council of Advisors on Science and Technology. âEducation spurs research and innovation, which draws entrepreneurs and builds engagement with the community, which increases the need for educated workers in that field, and so on.â
Valuable collision spaces
Brian Darmody, AURP chief strategy officer, is the author of several white papers on the value of research parks. He noted that innovation districts Improve the likelihood that student talent remains in an area, instead of being recruited elsewhere after graduation. This happens when students get to experience the robust ecosystem and facilities early on through internships or work experiences, such as those available with STAR Campus partners and tenants. These students then become part of the community, finding jobs, paying taxes, buying homes, growing families and otherwise contributing to the local economy.Â
Situating a diversity of businesses, nonprofits and researchers in one space also increases what Darmody calls âbumpability,â the likelihood that a researcher from one discipline could bump into someone working in a different technology area and discover some common ground.Â
âUDâs STAR Campus is an example of a well-designed collaboratory, where people can have their own independent space but have lots of reasons to meet with other folks,â Darmody said.
The 2023 international conference of the Association of University Research Parks drew more than 240 research park leaders and innovation district leaders from around the world to UDâs Science Technology and Advanced Research (STAR) campus.
These opportunities and connections provide staying power for area businesses and generate tax revenue for the state, acting as an economic driver.
âWhen you put nonprofits, academia and private industry together in one ecosystem, innovation and research translation accelerates; student experience, learning and hiring grows,â said Tracy Shickel, associate vice president of corporate engagement at UD and AURP board member.
AURP visitors had the opportunity to tour leading-edge STAR Campus facilities, including NIIMBL â the National Institute for Innovation in Manufacturing Biopharmaceuticals. NIIMBL is a Manufacturing USA network of over 200 members headquartered in the Ammon Pinizzotto Biopharmaceutical Innovation Center and focused on improving biopharmaceuticals manufacturing and educating the future biopharmaceutical workforce. They also visited the FinTech Innovation Hub, the latest gem in UDâs innovation neighborhood, centered on work aimed at improving equity in financial services and health.
A moderated panel discussion on the transformative role of hydrogen in clean energy research provided AURP members an overview of cutting-edge technologies, applications and policies that will power a more sustainable future for society. UD is a trailblazer in this area, collaborating to accelerate technology development through its Center for Clean Hydrogen, launched in 2023, and building the regionâs clean energy workforce through its role in the recently announced Mid-Atlantic Clean Hydrogen Hub.
Attendees also learned how corporate-university connections are changing the way JPMorgan Chase hires its technology talent. According to Jennifer McDermott, JPMC executive director of global technology workforce strategy, one out of every three employee roles at JPMC are tech related, amounting to about 55,000-60,000 technologists across the financial services company. These jobs are not only in high demand, but they are also higher-paying jobs.
Proximity to talent and diversity is key to sustaining a strong technology pipeline, she said, as are programs that provide alternative pathways for talent development. UDâs Spectrum Scholars, a college-to-career program designed to break down barriers to access for students with autism collaboratively developed by UD and JPMC, is one such example.Â
Gov. John Carney recalled Delawareâs evolution over the last 50 years from a state well-known for a few large employers, such as the DuPont Company and Chrysler, to a small business state with a bustling innovation-based economy.Â
âWe knew to be successful as a state we had to diversify our economy. We had to get focused on small business and science and technology-based companies, and thatâs what we did,â Carney said.
The transformation of UDâs STAR Campus â the site of a former Chrysler automotive plant â is a shining example of this in action. Today, more than 3,000 people work on the STAR Campus, a greater number than when the automotive plant was producing Dodge Durangos more than 20 years ago.Â
Delaware State University (DSU), a Historically Black College and University (HBCU) located in Dover, Delaware, is moving in the same direction, working to develop science and technology-based innovation and businesses, and preparing students to be leaders in the workforce of the future.
Keynote speaker Tony Allen, president of Delaware State University, a UD alumnus and former member of UDâs Board of Trustees, spoke about the wealth of talent in Historically Black Colleges and Universities (HBCUs) and the value they bring to powering an innovation pipeline.
Keynote speaker Tony Allen, president of DSU, spoke about the value of HBCUs in powering this innovation pipeline. HBCUs, Allen said, comprise a mere 3% of universities nationwide, yet these institutions educate 20% of Black graduates. This amounts to nearly 300,000 graduates annually. Allen, who is a UD alumnus, is interested in building capacity for businesses to grow on HBCU campuses and leverage this sometimes-untapped wealth of talent.
âWhen you think about the ability to change lives across any discipline, think about how important it is to bring diversity of people, experience and ideas into the marketplace,â said Allen, who chairs President BidenâsÂ Board of Advisors on Historically Black Colleges and Universities. âThink about what that will mean for our country and for our smaller, globally connected world and how you can partner with our HBCUs.â
Carney said there are reasons for Delawareâs success. Borrowing a phrase from his predecessor, former Gov. Jack Markell, Carney referred to Delaware as âa state of neighbors,â saying, âI just love that terminology, because weâre very small, barely one million people, and we have this tradition of knowing one another and working together to get things done.âÂ
Efforts to shore up gaps in Delawareâs innovation ecosystem are an apt example of this. Take UDâs three University-related research campuses, for example: Delaware Technology Park and UDâs STAR Campus in Newark, and the Innovation Space in Wilmington.Â
âAs companies or startups formed, and technologies were licensed, we had incubation space for them, but as they grew, they often had to move out of the region,â Shickel said.Â
Through partnerships with state elected officials, the university and commercial real estate market, those gaps have been filled, so that businesses like Prelude Therapeutics, a clinical-stage biopharmaceuticals company, now have support and space to expand. Prelude Therapeutics started at STAR Campus, grew to the Innovation Space, and now is putting its permanent headquarters at the Chestnut Run Innovation and Science Park (CRISP) campus in Wilmington, Delaware.Â
And while the development at STAR Campus has been tremendous over the last decade, Shickel said, with just over 10% of the 272 acres on the STAR campus currently developed, theyâve barely scratched the surface of whatâs possible.
âThis is a tremendous economic and innovation impact success story,â Shickel said.Â
Throughout the remainder of the conference, AURP members had the opportunity to visit a cross-section of other regional innovation ecosystem models with varying funding mechanisms, ownership models, missions, objectives and tenant mixes, including The Mill in Wilmington and the Brandywine Realty Trust in Philadelphia, Pennsylvania.
Wed, 25 Oct 2023 12:00:00 -0500entext/htmlhttps://www.udel.edu/udaily/2023/october/star-campus-association-of-university-research-park-international-conference/See the Gates in Action
Type of gate: disappearing oscillating buoyancy flap gate
Number of gates: 4 rows at three locations (Lido, 2 rows; Malamocco, 1 row; Chioggia, 1 row)
Number of individual gate sections: 79 (Lido, 41; Malamocco, 20; Chioggia, 18)
Individual gate dimensions: 66 feet wide, 15.5 feet thick, 99 feet long at deepest point
Weight of each gate: 250 - 350 tons
Height of tides when gates operate: 40 inches or more above average
Average lagoon inlet closure time: 4.5 hours
Time necessary to open the gates: 30 minutes
Time necessary to close the gates: 15 minutes
Maximum difference in level between sea and lagoon when gates are raised: 6.6 feet
Cost of the project: $1.9 billion
Project execution time: 8 years
Number of direct jobs during execution: 1,000 per year
Number of direct jobs when fully operational: 150 per year
Maintenance and management costs: $9.2 million per year ($6.2 million for maintenance, $3 million for management)
Tue, 13 Sep 2011 18:09:00 -0500entext/htmlhttps://www.pbs.org/wgbh/nova/venice/gates.htmlRegenacy is poised to deliver the first treatment for peripheral neuropathy
Peripheral neuropathy affects nerves outside of the brain and spinal cord. Dysfunction of these nerves can cause spontaneous, inappropriate signals or loss of signals, leading to symptoms such as pain and numbness. This condition affects more than half of all diabetic adults, approximately 500,000 chemotherapy-treated patients, and an estimated one million individuals with an inherited degenerative nerve condition called CharcotâMarieâTooth disease type 2 (CMT2). Peripheral neuropathy can cause severe disability and increases the risk of limb amputation, which significantly diminishes quality of life, but currently there is no approved treatment. Regenacy Pharmaceuticals is developing a novel, disease-modifying approach to treating peripheral neuropathies that goes beyond pain and symptom management to restore peripheral nerve function. The companyâs lead compound ricolinostat is an oral, selective inhibitor of the microtubule-modifying enzyme histone deacetylase 6 (HDAC6). With first-in-class potential, ricolinostat is currently positioned to enter a phase 2 clinical trial for diabetic neuropathic pain.
âTemporary, symptomatic treatments for neuropathic pain are poorly tolerated, minimally effective and addictive,â said Regenacyâs vice president of research and development Matthew Jarpe. âUnlike approved medicines, ricolinostat is well tolerated, non-addictive, and has potential to achieve lasting relief of all neuropathy symptoms rather than transient relief of some symptoms.â
Restoring nerve function
Neurons conducting signals to and from the spinal cord into the feet and hands are the longest cells in the body. These neurons rely on an internal micro-tubule transport network to supply energy and nutrients to maintain nerve ends in the skin and muscles. When this transport is disrupted by disease nerve cells can malfunction and send random signals, resulting in pain, tingling, muscle spasms, or no signal at all, leading to numbness or paralysis. These are the symptoms of peripheral neuropathy that can result from diabetes, chemotherapy, and mutations.
Intracellular transport is regulated by HDAC6âa microtubule-associated deacetylase that plays a significant role in axonal functioning in the nervous system. Inhibition of HDAC6 is a novel approach to restoring nerve function for the treatment of peripheral neuropathies by re-establishing the transport function of microtubules (Fig. 1). Phase 1 and 2 clinical trials in 250 cancer patientsâ demonstrated ricolinostatâs excellent safety and tolerability profile, particularly when contrasted with the high toxicity of currently marketed, nonspecific pan-HDAC inhibitors such as vorinostat and panobinostat.
Moreover, preclinical studies in multiple models of genetic and induced forms of peripheral neuropathy provide compelling evidence that HDAC6 inhibition normalizes the function of damaged peripheral nerves. In animal models of chemotherapy-induced neuropathy, ricolinostat reduces pain and numbness, restores nerve function, promotes nerves to grow back into the skin, and exerts long-lasting effects that persist for days after the end of dosing, suggesting a disease-modifying capability. Similar effects are seen in models of diabetic neuropathy and CMT2. âWe plan to explore the efficacy of ricolinostat in diabetic peripheral neuropathy patients first,â Jarpe said. âLater we will expand into chemotherapy induced neuropathy and CMT2.â
Currently, Regenacy is seeking additional partnerships to develop its portfolio of HDAC inhibitors.
Recently, the company announced a collaboration with the CharcotâMarieâTooth Association, a non-profit organization serving the hereditary neuropathy patient community, to validate the role of HDAC6 in multiple forms of CMT2 and evaluate the efficacy of ricolinostat in animal models to support the initiation of clinical trials.
âWe are thrilled to have such a substantial collaboration to broaden our programs for ricolinostat into inherited forms of neuropathy where there is a tremendous unmet need,â Jarpe said. âThis and future alliances will position us to deliver a superior, first-in-class treatment for peripheral neuropathies, which affect many millions of people worldwide.â
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